Endocrine Abstracts

It is known that functional hypothalamic amenorrhea is associated with low bone turnover due to low gonadal homone levels. Estrogens are critical for activation of bone remodelling units, suppression of bone reabsorption, increase of 1-25(OH)Vitamin D receptors expression. Other mechanisms could be operative, including improper diet and unbalanced exercise; however the physiopathology of such a condition is not entirely known. In order to evaluate the correlation between pitui...

It is well known that insulin resistance (IR) is associated with polycystic ovary syndrome (PCOS). Oxidative stress (OS) is, in turn, related to IR, with a vicious cycle. PCOS patients presented higher circulating concentrations of oxidative stress products such as homocysteine, malondialdehyde, an increase of superoxide dismutase and reduction of antioxidants such as glutathione and paraoxonase-1 activity. Most studies however concerned obese PCOS subjects. The physiopatholog...